About: Caffeine Clearance – Beverage Genetics

About: Caffeine Clearance

Average Canadians drink approximately 210 milligrams of Caffeine (1,3,7-Trimethylpurine) per day, or 1.2 mg of caffeine per kilogram of body weight, however recommendations for caffeine consumption relate to mass and do not take individualized caffeine clearance rates into consideration (Reyes, & Cornelis 2018, Heckman, Weil, & De Mejia, 2010). The molecular pathways and pharmacokinetics for caffeine enzymatic metabolism have been well characterized as seen in the featured image. Well understood genetic polymorphisms guide the production of metabolic enzymes for the processing of caffeine within the P450 cytochorme pathway (Zhou, Yang, Zhou, Liu, & Chan, 2009). Genes associated with the CYP1A2 have also been characterized, and outlined in detail (Consortium et al., 2015; Thorn, Aklillu, McDonagh, Klein, & Altman, 2012). Single Nucleotide Polymorphisms (SNPs) have been linked to individualized results and outcomes for caffeine metabolism. These SNPs can be measured using well established consumer genetics protocols which enables us to inform you about the amount of caffeine your liver can process, and therefore recommend an appropriate amount of caffeine to you based on your SNPs at the associated regions of interest.

We peek at these SNPs to ensure that we are able to link you with the right coffee, for peak enjoyment. To us that means, avoiding some of the side effects you may have felt from your previous coffee while still enjoying some of benefits from caffeine. Get the right amount of caffeine to help you wake up in the morning, run your day without the irritating side effects of over caffeination so you can sleep peacefully at night.  


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